Mary Thoma

PhD Candidate, UCSF

Can you describe the research you’re working on as part of TIME-AD?

I am involved primarily in Project 4, which focuses on the relationship between social isolation and ADRD. I am using target trial emulation methods to assess potential social interventions, such as the potential impact of volunteering, and comparing the effects of in-person vs. digital social interventions. 

Why is your work important, and what do you wish more people understood about it?

Social isolation is increasingly recognized as a major public health concern (just ask the Surgeon General). Especially as we become more digitally connected, many people across the lifespan are becoming less socially connected. In older adulthood, social isolation can lead not only to loneliness and worse mental health, but is also a serious risk factor for a wide range of physical health outcomes, including cognitive decline and dementia. My work focuses on understanding how social isolation contributes to cognitive aging and how we can most effectively intervene. Social isolation is an incredibly complex and multifaceted construct, with many potential intervention strategies. To address it meaningfully, we must take a causal inference approach that considers what types of social connection are most protective for long-term cognitive health. 

What do you enjoy doing outside of work?

Snow skiing in the winter and camping in the summer! 

If you weren’t a scientist, what do you think you’d be doing?

I have previously worked as a caretaker for an older adult with severe vision loss. If I was not doing research on social and cognitive health, I would want to find a way to work directly with older adults to help maintain independence, social connection, and healthy years of life.